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The deviation of man from the state in which he was originally placed by nature seems to have proved to him a prolific source of diseases.
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The joy I felt as the prospect before me of being the instrument destined to take away from the world one of its greatest calamities [smallpox] was so excessive that I found myself in a kind of reverie.
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"An Inquiry into Cause and Effects of the Variolae Vaccinae, a Disease Discovered in Some of the Western Countries of England, Particularly Gloucestershire, and Known by the Name of CowPox"
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"I shall endeavour still further to prosecute this inquiry, an inquiry I trust not merely speculative, but of sufficient moment to inspire the pleasing hope of its becoming essentially beneficial to mankind."
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"I hope that some day the practice of producing cowpox in human beings will spread over the world -- when that day comes, there will be no more smallpox."
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